Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212
نویسندگان
چکیده
منابع مشابه
Preclinical Development Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212
The MEK1 and MEK2 inhibitor GSK1120212 is currently in phase II/III clinical development. To identify predictive biomarkers, sensitivity toGSK1120212was profiled for 218 solid tumor cell lines and 81 hematologic malignancy cell lines. For solid tumors, RAF/RAS mutation was a strong predictor of sensitivity. Among RAF/RAS mutant lines, co-occurring PIK3CA/PTEN mutations conferred a cytostatic re...
متن کاملComprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
The MEK1 and MEK2 inhibitor GSK1120212 is currently in phase II/III clinical development. To identify predictive biomarkers, sensitivity to GSK1120212 was profiled for 218 solid tumor cell lines and 81 hematologic malignancy cell lines. For solid tumors, RAF/RAS mutation was a strong predictor of sensitivity. Among RAF/RAS mutant lines, co-occurring PIK3CA/PTEN mutations conferred a cytostatic ...
متن کاملCancer Therapy: Preclinical GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition
Purpose: Despite their preclinical promise, previous MEK inhibitors have shown little benefit for patients. This likely reflects the narrow therapeutic window for MEK inhibitors due to the essential role of the P42/44 MAPK pathway in many nontumor tissues. GSK1120212 is a potent and selective allosteric inhibitor of theMEK1 andMEK2 (MEK1/2) enzymes with promising antitumor activity in a phase I...
متن کاملGSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.
PURPOSE Despite their preclinical promise, previous MEK inhibitors have shown little benefit for patients. This likely reflects the narrow therapeutic window for MEK inhibitors due to the essential role of the P42/44 MAPK pathway in many nontumor tissues. GSK1120212 is a potent and selective allosteric inhibitor of the MEK1 and MEK2 (MEK1/2) enzymes with promising antitumor activity in a phase ...
متن کاملPredictive validity of the comprehensive basic science examination (CBSE) for success assessment of comprehensive preintership examination (CPIE) in medical students
Introduction. One of the proplems that both medical students and educational programmers are involved in is the importance of basic science materials in comprehention of clinical subjects and student's performance after that. Our goal is to measure the correlation coefficient between the CBSE and CPSE and the predictive validity of CBSE for CPIE. Methods. Analytic cross-sectional study was co...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2011
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-11-0505